LIPOPROTEIN ANALYSES IN PATIENTS WITH STABLE ANGINA AND ACUTE CORONARY SYNDROME

We have performed lipid analyses by using a table-top ultracentrifuge based on the Hatch and Lees' method in 77 subjects (60 men, 17 women; mean age, 63 years) to clarify lipoprotein disorders in coronary arter y disease. Sixty-four subjects had coronary artery disease and 13 norm al subjects were controls. They were divided into the groups with stab le angina pectoris and with unstable angina pectoris or acute myocardi al infarction (acute coronary syndromes). In patients with coronary ar tery disease, there were no significant differences from control in ag e, body mass index, total cholesterol, however, HDL cholesterol was si gnificantly lower than those in the controls. LDL cholesterol:LDL apoB ratio, which is thought to reflect the size of LDL in coronary artery disease, was significantly smaller than that in the controls; mean va lues were 1.2 in coronary artery disease and 1.4 in controls. There we re no significant differences in those lipoprotein disorders between t he patients with stable angina and those with acute coronary syndromes . Though these lipoprotein abnormalities would not play a trigger role in acute coronary syndromes, they are characteristic of the lipid pro file of patients with coronary artery disease.