Aa. Ajayi et al., CONCURRENT ALPH(1), ADRENERGIC-BLOCKADE AND ANGIOTENSIN-CONVERTING ENZYME-INHIBITION IN THE TREATMENT OF CONGESTIVE-HEART-FAILURE, International journal of cardiology, 57(2), 1996, pp. 173-176
We tested the hypothesis that concurrent inhibition of the renin angio
tensin system by enalapril (5 mg) and the sympathetic nervous system b
y alpha(1) adrenergic blockade (prazosin 1 mg) will be superior to ena
lapril alone in 17 patients with heart failure on standard therapy, in
a single blind, placebo-controlled, randomized parallel group study f
or 4 weeks. Enalapril alone induced a significant increase in exercise
time from 499+/-412 s to 707+/-608 s (P<0.05, ANOVA), but the increas
e induced by the enalapril+prazosin combination was significantly grea
ter (P<0.025, MANOVA) from 214+/-271 to 1007+/-784 s as was the increa
se in creatinine clearance (P<0.05).