THE EFFECT OF LINOMIDE ON THE MIGRATION AND THE PROLIFERATION OF CAPILLARY ENDOTHELIAL-CELLS ELICITED BY VASCULAR ENDOTHELIAL GROWTH-FACTOR

Authors
PARENTI A DONNINI S MORBIDELLI L GRANGER HJ ZICHE M
Citation
A. Parenti et al., THE EFFECT OF LINOMIDE ON THE MIGRATION AND THE PROLIFERATION OF CAPILLARY ENDOTHELIAL-CELLS ELICITED BY VASCULAR ENDOTHELIAL GROWTH-FACTOR, British Journal of Pharmacology, 119(4), 1996, pp. 619-621
Citations number
9
Categorie Soggetti
Pharmacology & Pharmacy",Biology
Journal title
British Journal of Pharmacology → ACNP
ISSN journal
00071188
Volume
119
Issue
4
Year of publication
1996
Pages
619 - 621
Database
ISI
SICI code
0007-1188(1996)119:4<619:TEOLOT>2.0.ZU;2-8
Abstract
In order to assess the mechanism of action of the quinoline-3-carboxya mide linomide as an antiangiogenic drug, the effect of linomide was st udied in vitro on postcapillary endothelial cells exposed to vascular endothelial growth factor (VEGF). Linomide did not block the spontaneo us replication of endothelial cells, but significantly suppressed endo thelial cell growth and migration elicited by VEGF. It is concluded th at linomide appears to be an effective tool to inhibit VEGF-dependent angiogenesis.