RELATIONSHIP BETWEEN ANTIGENICITY AND IMMUNOGENICITY OF CHIMERIC HEPATITIS-B VIRUS CORE PARTICLES CARRYING HIV TYPE-I EPITOPES

Authors
GRENE E MEZULE G BORISOVA G PUMPENS P BENTWICH Z ARNON R
Citation
E. Grene et al., RELATIONSHIP BETWEEN ANTIGENICITY AND IMMUNOGENICITY OF CHIMERIC HEPATITIS-B VIRUS CORE PARTICLES CARRYING HIV TYPE-I EPITOPES, AIDS research and human retroviruses, 13(1), 1997, pp. 41-51
Citations number
52
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
AIDS research and human retroviruses → ACNP
ISSN journal
08892229
Volume
13
Issue
1
Year of publication
1997
Pages
41 - 51
Database
ISI
SICI code
0889-2229(1997)13:1<41:RBAAIO>2.0.ZU;2-J
Abstract
We have developed a comparative study of antigenic and immunogenic pro perties of selected immunodominant HIV-1 epitopes from p24 and gp120 p roteins added to C-terminally truncated hepatitis B virus (HBV) core p rotein and exposed on the surface of chimeric core particles. Inserted p24 (121-210) and gp120/MN (306-328) epitopes induced the appropriate humoral and cellular immune responses against HIV-1. Superficially ex posed region 160-192 of p24 also showed maximal B cell immunogenicity whereas buried region 148-162 induced maximal T cell response. Both re combinant proteins were also able to be recognized in vitro by T lymph ocytes of HIV-1 asymptomatic carriers.