FAILURE OF INSULIN-LIKE GROWTH-FACTOR TYPE-I TO SUPPRESS HIV TYPE-1 IN ADULT OR UMBILICAL-CORD MONONUCLEAR BLOOD-CELLS

Authors
SHARMA UK SONG HF CASELLA SJ SCHWARTZ DH
Citation
Uk. Sharma et al., FAILURE OF INSULIN-LIKE GROWTH-FACTOR TYPE-I TO SUPPRESS HIV TYPE-1 IN ADULT OR UMBILICAL-CORD MONONUCLEAR BLOOD-CELLS, AIDS research and human retroviruses, 13(1), 1997, pp. 105-110
Citations number
20
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
AIDS research and human retroviruses → ACNP
ISSN journal
08892229
Volume
13
Issue
1
Year of publication
1997
Pages
105 - 110
Database
ISI
SICI code
0889-2229(1997)13:1<105:FOIGTT>2.0.ZU;2-D
Abstract
Insulin-like growth factor type I (ICE-I) has been used as a treatment for cachexia in adults with AIDS and has been reported to show inhibi tory activity against HIV-1(IIIB) in cord blood mononuclear cells (CBM Cs) in vitro at low-concentration (1%) fetal bovine serum (FCS), We ev aluated the effect of IGF-I on MN, IIIB, and Bat strains, as well as o n a patient isolate of HIV-1 in CBMCs and adult peripheral blood monon uclear cells (PBMCs). IGF-I failed to show any inhibitory effect on HI V replication in CBMCs or adult PBMCs under various culture conditions , In contrast to an earlier report of an antiviral effect.