TREATMENT OF CHRONIC HEPATITIS-B AND HEPATITIS-C WITH INTERFERON ALFA-2B

Chronic viral hepatitis B and C are problems of immense proportions. I nterferon alfa-2b is the only agent currently approved by the U.S. Foo d and Drug Administration for the treatment of chronic hepatitis B and C. Initial enthusiasm for this therapy has waned with the realization that response rates are low and relapses are common. Recent studies, however, provide evidence of improved response rates with higher doses of interferon alfa-2b and the use of this agent in combination with i ron reduction therapy consisting of repeated phlebotomies. Predictors of an increased likelihood of response to interferon alfa-2b therapy h ave also been identified, and their use may improve the cost-benefit r atio for this treatment.