Authors
Citation
Dg. James, A NEW IMMUNOSUPPRESSANT - TACROLIMUS, Postgraduate medical journal, 72(852), 1996, pp. 586-586
Citations number
3
Categorie Soggetti
Medicine, General & Internal
Journal title
ISSN journal
00325473
Volume
72
Issue
852
Year of publication
1996
Pages
586 - 586
Database
ISI
SICI code
0032-5473(1996)72:852<586:ANI-T>2.0.ZU;2-N
Abstract
Tacrolimus is the new name for the Japanese immunosuppressant drug FK5
06. It blocks interleukin 2 transcription thereby inhibiting the CD4 T
h-1 lymphocyte response to foreign antigens. It also selectively inhib
its cytokine secretion of IL3, IL4 and interferon-gamma. It is metabol
ised by the cytochrome P-450 enzyme system. The results of two trials
indicate that it is similar to cyclosporin in efficacy and toxicity.