The present study examined traditional risk factors and various indice
s of emotional distress in males with positive angiograms (N = 122), '
'syndrome X'' males with negative or nominal results on angiogram (N =
53), and age- and socioeconomic status-matched males with no manifest
history of atherosclerotic disease (N = 56). Syndrome X patients repo
rted more depression on the Ketterer Stress Symptom Frequency Checklis
t (KSSFC) than positive angiographic patients. And compared with healt
hy controls, they were more likely to be perceived by a spouse/friend
as depressed and anxious on the KSSFC, scored higher on the Framingham
Type A Scale, and reported more unprovoked nocturnal awakening. Syndr
ome X patients generally appear to be similar to patients with positiv
e angiograms with regard to traditional risk factor history but are mo
re distressed than healthy controls. This becomes most evident when de
nial is circumvented by discussion with significant others or inquirie
s are ''framed'' appropriately.