Tight metabolic control as assessed by estimation of glycated hemoglob
in or albumin seems to be the main prophylactic factor in the preventi
on of most diabetic complications. By regular monitoring of the kidney
size, GFR, and urinary albumin excretion, detection of early (reversi
ble) diabetic nephropathy is possible. By appropriate dietary (protein
restriction) and pharmacological (ACEI, antihypertensive drugs) treat
ment development of overt diabetic nephropathy may be prevented or mar
kedly slowed.