MULTIVARIATE ANALYSES OF PROGNOSTIC FACTORS ASSOCIATED WITH HEMATOPOIETIC RECOVERY IN AUTOGRAFT PATIENTS WITH DIFFERENT SOURCES OF PROGENITOR CELLS - A GATMO EXPERIENCE

Objective: To evaluate in a multivariate analysis the prognostic facto rs associated with hematopoietic recovery and the supportive care requ irements after autotransplant of progenitor cells (PC) from various so urces: bone marrow (BMPC), BMPC & peripheral blood (PBPC), and PBPC al one. Patients and methods: A total of 570 patients with hematological malignancies and solid tumors underwent high-dose therapy followed by autotransplant. PBPC were obtained after mobilization with chemotherap y and/or cytokines. One-hundred five patients received BMPC, 217 recei ved BMPC & PBPC and 248 PBPC alone; all of the patients received G-CSF or GM-CSF after infusion. Results: in a multivariate analysis the rec overy of neutrophils was adversely associated with low numbers of nucl eated cells infused (P < 0.13), bone marrow progenitor cell source, an d diagnosis of multiple myeloma and acute leukemia (P < 0.001). The fa ctors that adversely affected platelet recovery were low number of nuc leated cells and diagnosis of multiple myeloma and acute leukemia (P < 0.001). Conclusion: We conclude that BMPC adversely affect neutrophil recovery while low numbers of nucleated cells and diagnosis of multip le myeloma and acute leukemia adversely affect both neutrophil and pla telet recovery.