D. Lapenna et al., CAPTOPRIL HAS NO SIGNIFICANT SCAVENGING ANTIOXIDANT ACTIVITY IN HUMANPLASMA IN-VITRO OR IN-VIVO, British journal of clinical pharmacology, 42(4), 1996, pp. 451-456
1 Captopril has been reported to possess hydroxyl radical(OH)and hypoc
hlorous acid (HOCl) scavenging effects, which could contribute to its
therapeutic activity in the clinical setting. 2 The objective of the p
resent study was to determine whether therapeutically achievable capto
pril concentrations could augment antioxidant properties of human plas
ma and protect it against OH .- and HOCl-driven oxidant injury in vitr
o. Possible drug influences on systemic oxidative stress status in viv
o were also investigated in subjects taking 50 mg captopril orally by
measuring plasma and red blood cell peroxidation, as well as plasma pr
otein thiols. 3 The results show that captopril is incapable of enhanc
ing antioxidant properties of human plasma, of protecting it against s
pecific oxidative attack and of decreasing systemic oxidant load in vi
vo. 4 The present data, therefore, do not support the contention of a
beneficial action of captopril through systemic antiradical-antioxidan
t effects in human beings.