EFFECTS OF FRUSEMIDE ON THE URINARY-EXCRETION OF DOPAMINE AND 5-HYDROXYTRYPTAMINE IN NORMAL MAN

Authors
WA TCLK FREESTONE S MCCRINDLE JL SAMSON RR JOHNSTON NR LEE MR
Citation
Tclk. Wa et al., EFFECTS OF FRUSEMIDE ON THE URINARY-EXCRETION OF DOPAMINE AND 5-HYDROXYTRYPTAMINE IN NORMAL MAN, British journal of clinical pharmacology, 42(4), 1996, pp. 522-524
Citations number
15
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
British journal of clinical pharmacology → ACNP
ISSN journal
03065251
Volume
42
Issue
4
Year of publication
1996
Pages
522 - 524
Database
ISI
SICI code
0306-5251(1996)42:4<522:EOFOTU>2.0.ZU;2-Y
Abstract
The effects of frusemide on the urinary excretion of dopamine and 5-hy droxytryptamine (5-HT) were investigated in eight healthy male subject s in a randomized, placebo-controlled, cross-over study. Frusemide pro duced the expected rise in urinary dopamine excretion but it did not a ffect 5-HT excretion when compared with placebo. The lack of an effect on 5-HT excretion in man contrasts with studies in the rat which have reported a marked increase in 5-HT excretion after administration of this loop diuretic.