HYPEROXIA-INDUCED CHANGES OF GENE-EXPRESSION IN RAT-BRAIN AND LUNGS

Differential hybridization of cDNA libraries obtained from brain and l ungs of rats maintained at 80% oxygen has shown alterations in mRNA co ntent of some genes. Concentration of mRNA for NADH dehydrogenase and cytochrome b decreased in both brain and lungs. Along with that, lower concentrations of mRNA of cytochrome c oxidase and to an unknown gene were detected in lungs, and higher concentrations of mRNA transcripts of the specific identifier sequence (ID), an unknown gene, and a gene probably encoding calmodulin were found in brain.