Je. Morley et al., AMYLIN AND FOOD-INTAKE IN MICE - EFFECTS ON MOTIVATION TO EAT AND MECHANISM OF ACTION, Pharmacology, biochemistry and behavior, 56(1), 1997, pp. 123-129
Amylin is a hormone produced by the pancreatic islets of Langerhans. A
mylin decreased food pellet consumption. Amylin also decreased lever p
ressing for milk solution whether or not the mice were prefed. Amylin
did not produce a conditioned taste aversion in a two bottle test, whe
reas lithium chloride did. In addition, L-arginine, a precursor for ni
tric oxide synthesis, was demonstrated to inhibit the ability of amyli
n to decrease food intake. Amylin did not alter nitric oxide synthase
activity in the fundus of the stomach. These studies demonstrated that
amylin inhibits food intake at a higher range of doses than is typica
l of anorectic agents such as cholecystokinin. Amylin does not appear
to decrease food intake by reducing the release of nitric oxide but ma
y affect appetite by modulating serum glucose levels when co-released
with insulin. Copyright (C) 1997 Elsevier Science Inc.