ALZHEIMERS-DISEASE AND BETA-AMYLOID - PATENT ACTIVITY BETWEEN MAY 1995 AND JULY 1996

The patent literature describing activity relating to beta-amyloid (A beta) and Alzheimer's disease (AD) from May 1995 to July 1996 is revie wed. Inventions are classified into five groups: therapeutics that inf luence A beta production, therapeutics based on interfering with A bet a aggregation and deposition, therapeutics based on interfering with A beta neurotoxicity, diagnostics and animal models. While new chemical entities are described as therapeutic agents, the clinical developmen t of these compounds is hindered by the lack of a widely available ani mal model which mimics the pathology of AD.