CYCLODEXTRIN SIDE-CHAIN POLYESTERS - SYNTHESIS AND INCLUSION OF ADAMANTAN DERIVATIVES

An efficient synthesis of a cyclodextrin polymer by a polymer-analogou s reaction of lithium beta-cyclodextrinate with poly[(N-vinyl-2-pyrrol idinone)-co-(maleic anhydride)] is described. Because cyclodextrin pol ymer is highly water-soluble, its binding of guests, like 1-adamantana mine and 1-adamantanecarboxylic acid, could be investigated by titrati on microcalorimetry. All cyclodextrin moieties are accessible by the g uest within the polymer, but binding constants are slightly lower than those for native beta-cyclodextrin. Binding constants are influenced by Coulomb interactions between the guest and the anionic polymer back bone.