RENAL MANIFESTATIONS OF TUBEROUS SCLEROSIS COMPLEX

Patients with tuberous sclerosis complex (TSC) are at increased risk o f renal disease, predominantly angiomyolipomas and renal cysts. We ret rospectively reviewed clinical data of 71 patients diagnosed with TSC, Progression of renal lesions was noted. TSC patients with renal lesio ns were compared with TSC patients without renal disease. Fifteen of 3 8 patients had renal abnormalities by imaging at presentation. Six of 9 with initially normal kidneys subsequently developed new lesions, Al though not of statistical significance, there was a trend toward incre ased retinal hamartomas, cardiac rhabdomyomas, and skill lesions in th ose patients who also had renal abnormalities, Renal disease should be considered and sought in all patients with TSC, both at initial prese ntation and subsequently, since renal disease is a very significant ca use of morbidity and mortality.