The Medicinal Chemistry Section of IUPAC sent a questionnaire regardin
g academic training for medicinal chemists to major research pharmaceu
tical companies in various countries in July 1992 and again in July 19
93. A total of 102 replies were received from 65 companies, mainly fro
m Germany, Italy, Japan, the VK and the USA, and these have been analy
sed and the results are presented. Most companies (> 90%) indicated th
at they seek to hire organic chemists who may have received some addit
ional education in medicinal chemistry, rather than hire specialists i
n medicinal chemistry. The subjects most often mentioned as being desi
rable for the additional education were biochemistry (or drug metaboli
sm and pharmacokinetics), pharmacology and physiology, computer modell
ing and QSAR, and molecular biology.