PULPAL LESIONS IN NORMAL AND CYCLOSPORINE-A TREATED RATS

The objective of this study was to examine the development of pulpal l esions in the lower molar of control and cyclosporin A (CyA) treated r ats, The pulps of the first lower molars of 20 normal and 20 CyA treat ed rats were exposed and left open into the oral cavity, Five animals of each group were killed at 7, 14, 21, and 28 days after the pulp exp osure, The specimens were sectioned sagittally at a thickness of 7 E-c m and stained with hematoxylin and eosin, The pulpal lesions were simi lar for both normal and CyA treated rats in all studied periods and th e differences between both groups were not statistically significant b y the Student t test at the 5% (0.05) level of significance, indicatin g that the immunosuppression did not alter the evolution of the inflam matory process.