A general scheme has been developed for the assignment of chirality de
scriptors to chiral links and knots. For oriented links and knots, the
new D/L scheme employs linking numbers, self-writhes, and writhe prof
iles, in descending hierarchical order, with self-writhes and writhe p
rofiles limited to alternating links and knots. A related scheme appli
es to non-oriented links and knots. In a modification of a previous sc
heme, the use of vertex-bicolored digraphs is introduced in order to c
ompute writhe profiles of oriented links and knots. It is pointed out
that even though the different geometric presentations of each individ
ual chiral knot or link can be partitioned into homochirality classes,
the links and knots that belong to a given configurational class, D o
r L, are not homochirally similar.