N-IN-CYCLOHEXYLOXYCARBONYL GROUP AS A NEW PROTECTING GROUP FOR TRYPTOPHAN

Authors
NISHIUCHI Y NISHIO H INUI T KIMURA T SAKAKIBARA S
Citation
Y. Nishiuchi et al., N-IN-CYCLOHEXYLOXYCARBONYL GROUP AS A NEW PROTECTING GROUP FOR TRYPTOPHAN, Tetrahedron letters, 37(42), 1996, pp. 7529-7532
Citations number
9
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
42
Year of publication
1996
Pages
7529 - 7532
Database
ISI
SICI code
0040-4039(1996)37:42<7529:NGAANP>2.0.ZU;2-V
Abstract
Several new protecting groups were introduced at the N-in-position of tryptophan, and their reactivities were examined under the conditions used for peptide synthesis by Boc-strategy. Among them, the cyclohexyl oxycarbonyl (Hoc) group was found to be the most suitable in terms of stability during elongation of the peptide chain and removability at t he final HF reaction without resorting to the use of thiols. Copyright (C) 1996 Elsevier Science Ltd