USE OF F-19 NMR-SPECTROSCOPY TO EVALUATE REACTIONS IN SOLID-PHASE ORGANIC-SYNTHESIS

Gel-phase F-19 NMR spectroscopy has been used to characterize products from a variety of reactions of fluorinated aromatics linked to a Tent aGel resin. High quality spectra were obtained in a few minutes using an ordinary NMR spectrometer, and the F-19 chemical shifts of the supp ort-bound compounds closely matched those of soluble references. In ad dition, substantial chemical shift differences were obtained for almos t all of the synthetic transformations, illustrating the potential of F-19 NMR for rapid monitoring of reactions in solid-phase organic synt hesis. Copyright (C) 1996 Elsevier Science Ltd