BOTH THE H13 GENE-PRODUCT AND 4F2 ANTIGEN ARE INVOLVED IN THE INDUCTION OF SYSTEM Y(-ACID-TRANSPORT FOLLOWING ACTIVATION OF HUMAN PERIPHERAL-BLOOD MONONUCLEAR-CELLS (PBM)() CATIONIC AMINO)

Authors
CHEN S MEREDITH D BOYD CAR
Citation
S. Chen et al., BOTH THE H13 GENE-PRODUCT AND 4F2 ANTIGEN ARE INVOLVED IN THE INDUCTION OF SYSTEM Y(-ACID-TRANSPORT FOLLOWING ACTIVATION OF HUMAN PERIPHERAL-BLOOD MONONUCLEAR-CELLS (PBM)() CATIONIC AMINO), Biochimica et biophysica acta. Biomembranes, 1284(1), 1996, pp. 1-3
Citations number
11
Categorie Soggetti
Biology,Biophysics
Journal title
Biochimica et biophysica acta. Biomembranes → ACNP
ISSN journal
00052736
Volume
1284
Issue
1
Year of publication
1996
Pages
1 - 3
Database
ISI
SICI code
0005-2736(1996)1284:1<1:BTHGA4>2.0.ZU;2-6
Abstract
Prior transfection with antisense oligonucleotides to the H13 and 4F2 hc genes, singly or in combination, was found to inhibit phytohaemaggl utinin-induced activation of cationic amino-acid transport system y(+) in human peripheral blood mononuclear cells (mostly circulating lymph ocytes). These effects on system y(+) function or expression mean that 4F2 he cannot only be the molecular basis of system y(+)L (Fei, Y.-J. , Prasad, P.D., Leibach, F.H. and Ganapathy, V. (1995) Biochemistry 34 , 8744-8751).