NATURAL-HISTORY OF VESICOURETERAL REFLUX IN SIBLINGS

Purpose: We attempted to assess the natural course of vesicoureteral r eflux after it was detected in asymptomatic siblings of children with reflux, and to determine predictors of and time to resolution. Materia ls and Methods: We reviewed the records and radionuclide cystograms of 76 girls and 32 boys 2 weeks to 103 months old (mean age 21 months) w ith vesicoureteral reflux detected in a sibling screening program. Pre dictors were determined using logistic regression and survival analysi s. Results: Vesicoureteral reflux resolved in 52.8% of cases at a mean followup of 18.5 months, Yearly resolution rates exceeded 28%. Predic tors of the likelihood of resolution were not identified, At diagnosis unilateral reflux and mild reflux were independent and univariate pre dictors, respectively, of more rapid resolution. Conclusions: By showi ng that spontaneous resolution is likely for children with vesicourete ral reflux detected in a sibling screening program, this study support s nonsurgical management with annual imaging evaluation.