EFFECT OF SULPIRIDE ON BODY-WEIGHT AFTER CHRONIC ADMINISTRATION IN MALE-MICE

Although some studies indicate that sulpiride (an atypical neuroleptic drug) increases body weight in female rodents after long-term adminis tration, this action is less clear in males. In this study, we examine d the effect of three doses of sulpiride (40, 60 or 80 mg/kg, ip) or p hysiological saline, chronically administered during 9 consecutive day s, on body weight in the OF.1 strain of adult male mice. All animals w ere housed in transparent plastic cages during four weeks (non-drug pe riod) and weighted weekly. During the drug period, sulpiride was admin istered once daily for 9 days and body weights measured, Results showe d that sulpiride did not vary body weight after chronic administration , suggesting that the action of some neuroleptics on body weight might be a sex-dependent phenomenon.