BREAST-CANCER PROGNOSTIC-SIGNIFICANCE OF SOME MODIFIED URINARY NUCLEOSIDES

The prognostic significance of six urinary modified nucleosides, 5-met hylcytidine (5-MeCyd), 4-acetylcytidine (4-AcCyd), 1methylinosine (1-M eIno), 1-methyladenosine (1-MeAdo), 7-methylguanosine (7-MeGua) and ps eudouridine (Psi-Urd) was evaluated in 68 breast cancer patients of th e specialized cancer hospital of Lyon (France). Excretions of 1-MeIno and 1-MeAdo were significantly higher in patients hospitalized in the medical rather than surgical ward, reflecting more advanced disease, a nd also among patients who died within 5 years of follow-up as compare d to those still dye. These results suggest an unfavourable prognostic significance of high urinary excretion of 1-MeIno and 1-MeAdo in brea st cancer patients.