SW.B6-SOA(B) NONTASTER CONGENIC STRAINS COMPLETED AND A SUCROSE OCTAACETATE CONGENIC QUARTET TESTED WITH OTHER BITTERS

Ten SW.B6 SOA nontaster strains congenic with the SWR/J SOA taster inb red strain were bred via repeated backcross-intercross cycles, with se lection for nontasting in each cycle. Preference ratio distributions a nd phenotypic proportions across cycles at 0.1 mM SOA were consistent with monogenic predictions. The SW.B6 mice completed a congenic quarte t with the SWR/J, BG.SW SOA taster and C57BL/6J SOA nontaster strains. The Soa locus controlled avoidance differences within the quartet for SOA, raffinose undecaacetate, glucose pentaacetate and brucine. Backg round genes not linked to Soa controlled avoidance differences for L-p henylalanine and ethanol. Avoidance of bitter picric acid was influenc ed by the Soa locus, but avoidance of acetic acid was not. The quartet pattern for quinine HCl was unclear, with indications of both Soa and background effects. Two forms of ribose tetraacetate yielded differen t patterns. Avoidance differences controlled by the Soa locus were fou nd for the pyranose form; however, all four strains avoided the furano se form. The pleiotropic effects of Soa allele substitution within the quartet were limited to a subset of bitter compounds.