This study examined the relationship between the menstrual cycle, the
stress process. and migraines. Women migraineurs (N=12) and a matched
control sample (N=12) completed a set of questionnaires assessing stre
ss, appraisal, and coping at premenses, menses. and ovulation. In addi
tion, migraineurs completed a month of daily headache recording. Analy
ses revealed that the menstrual cycle affected subjects' use of coping
strategies and migraineurs' headache activity. Analyses also showed t
hat the covariation between stress and migraine varied across the mens
trual cycle. These results support the hypothesis of a three-way relat
ionship between menstrual cycle, stress, and migraine. We suggest that
physiological and/or psychological changes associated with premenses
may enhance or strengthen the relationship between stress and migraine
.