PERIOPERATIVE ANTIBIOTIC-PROPHYLAXIS BY T RANSPERITONEAL AND SUBCUTANEOUS APPLICATION DURING ELECTIVE COLORECTAL SURGERY - A PROSPECTIVE RANDOMIZED COMPARATIVE-STUDY

The prophylactic effect of a intraoperative intraperitoneal and subcut aneous application of cefazolin versus a single shot i. v. prophylaxis was investigated. Additionally, we registered the concentration of ce fazolin in the serum and the peritoneal fluid in 22 patients. We rando mized 200 patients of whom 189 were included in the study. Ninty-two p atients received the prophylaxis i.v. (group 1) and 97 topically (grou p 2). In 4 (2.1%) wound infections occurred [3 (3.3%) group 1 and 1 (1 .0%) in group 2]. The difference was not significant. The concentratio n of cefazolin in the serum was significantly higher at 1 h and 2 h po stoperatively in group 2. We conclude that a topical application of an tibiotics is possible to prevent surgical wound infection.