EFFECT OF PERMISSIVE HYPOTENSION IN CONTINUOUS UNCONTROLLED INTRAABDOMINAL HEMORRHAGE

Objective: To determine the effects of aggressive fluid administration vs permissive hypotension on survival, blood loss, and hemodynamics i n a model of uncontrolled hemorrhage in which bleeding has been shown to be continuous. Methods: In this porcine model, 10 animals were bled through a flow-monitored shunt placed between the femoral artery and the peritoneal cavity. The animals received either no fluid (n = 5) or 80 mL/kg lactated Ringer's solution (n = 5) during a resuscitation ph ase between 10 and 20 minutes postinjury, followed by a 40-minute eval uation phase. Arterial pressures, cardiac output (CO), and hemorrhage rate were measured. Survival and blood loss were calculated outcome me asures. Results: The difference in survival between the animals left h ypotensive (40%) and those receiving normotensive resuscitation (20%) was not significant (p = 0.49). In the animals receiving fluid resusci tation, mean arterial pressure (MAP) and CO increased during the resus citative phase, but all the animals suffered the same pattern of hemod ynamic deterioration in the evaluation phase. Rate of hemorrhage durin g the resuscitative phase was 20 +/- 5 mL/min in the animals not recei ving fluid and 56 +/- 9 mL/min in the animals receiving fluids. Total blood loss was subsequently 20 mL/kg greater in the animals receiving fluids than in the animals without fluid resuscitation. Conclusions: I n this model of continuous uncontrolled hemorrhage, the difference in survival between the animals left hypotensive and the animals receivin g fluid resuscitation was not statistically significant. Increases in MAP and CO with fluid resuscitation were transient and were offset by larger volumes of blood loss, In contrast to the aortotomy model (wher e thrombosis is likely and hypotensive resuscitation has proven benefi cial), this model suggests that in continuous bleeding, avoiding fluid resuscitation has a much smaller effect on outcome. Much of the benef it from hypotensive resuscitation may depend on having an injury that can stop bleeding.