EFFECTIVE CONTROL OF THE BACKGROUND STATE OF HEMOSTASIS IN THE PROCESS OF THERAPY WITH HEPARIN OF CARDIOLOGICAL PATIENTS

During therapeutic and preventive use of heparin the possibility to co ntrol the state of background hemostasis and to reveal concealed hyper coagulation is lost. By means of a sorption complex suggested by the a uthors it was possible to free investigated plasma from both unfractio nated and low molecular weight hepa tin and to determine the backgroun d state of the system of hemostasis. The use of the proposed sorbent i n the process of treatment of 75 patients with venous and arterial thr omboses, myocardial infarction and syndrome of disseminated intravascu lar coagulation, demonstrated the applicability of the method for diag nosis of hyper- and hypocoagulation concealed by heparin. Moreover ant ithrombin III deficit could be objectively revealed. The activity of a ntithrombin III equalized with its content in investigated plasma afte r application of the sorbent. The suggested method can be used for dis tinguishing hypocoagulation due to consumption of blood coagulation fa ctors from that caused by heparin.