APOPROTEIN C-III GENE POLYMORPHISM IN PAT IENTS WITH CORONARY-ARTERY DISEASE

DNA restriction fragment length polymorphism at the apoprotein C-III g ene locus were studied in 124 patients with coronary heart disease and 112 healthy subjects of Kazakh nationality, An Sst1 polymorphism loca ted in the 3' noncoding region of the apoC-III gene identified two all eles, The frequency of one of these alleles (S1) was significantly hig her in patients with coronary artery disease compared to control subje cts (p<0,05). Contrary to previously reported association of the S2 al lele with coronary artery disease in Caucasians in Kazakhs there was d ifference in frequency of S1 allele of the apoC-III gene between patie nts with coronary artery disease and control subjects, Thus apoC-III p olymorphism could be a marker of an abnormality in the apoC-III gene p redisposing to atherosclerosis in this national group.