The development of blood compatible materials has evolved through the
understanding of the importance of modulus matching of the implants ma
terial with human tissue, through surface chemistry adaptation to tiss
ue engineering. Analytical techniques involving labeling and spectrosc
opy have led to a better understanding of protein adsorption behavior
which is considered as the initial event for trombos formation. Signif
icant success in prolonging in vivo times for implants has been the re
sult However the complexity of the human defense system and of human b
ody parts still prevents us from making totally blood compatible impla
nts.