COMPARISON OF THE SUBSTRATE-SPECIFICITY OF TYPE-I AND TYPE-II DEHYDROQUINASES WITH 5-DEOXY-DEHYDROQUINIC AND 4,5-DIDEOXY-DEHYDROQUINIC ACID

Authors
HARRIS JM WATKINS WJ HAWKINS AR COGGINS JR ABELL C
Citation
Jm. Harris et al., COMPARISON OF THE SUBSTRATE-SPECIFICITY OF TYPE-I AND TYPE-II DEHYDROQUINASES WITH 5-DEOXY-DEHYDROQUINIC AND 4,5-DIDEOXY-DEHYDROQUINIC ACID, Journal of the Chemical Society. Perkin transactions. I, (19), 1996, pp. 2371-2377
Citations number
29
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of the Chemical Society. Perkin transactions. I → ACNP
ISSN journal
0300922X
Issue
19
Year of publication
1996
Pages
2371 - 2377
Database
ISI
SICI code
0300-922X(1996):19<2371:COTSOT>2.0.ZU;2-8
Abstract
Syntheses of 5-deoxydehydroquinic acid and 4,5-dideoxydehydroquinic ac id from quinic acid are described. These substrate analogues were test ed against the mechanistically-distinct type I and type II dehydroquin ases. The C-4 hydroxy group of the substrate is shown to be important for imine formation on the type I enzyme but appears not to contribute significantly to specificity on the type II dehydroquinase.