THE CHARGE ASSOCIATION

The CHARGE association is a polymalformative disease associating colob oma, heart disease, atresia of choanae, retarded growth and developmen t, genital hypoplasia and ear anomalies, CHARGE being an acronym based on these different malformations. The diagnosis requires at least fou r of these malformations including necessarily coloboma and/or atresia of choanae. The various clinical aspects, the genetics and the therap eutics implications are described.