EPILEPTOGENIC ACTIVITY-INDUCED BY COMBINED TREATMENT WITH ANTIINFLAMMATORY DRUGS AND ENOXACIN AND ITS INHIBITION BY A CALCIUM-ANTAGONIST, NICARDIPINE

Epileptogenic activity induced by combined treatment with antiinflamma tory drugs and enoxacin was investigated in chronic electrode-implante d rats. Ferubinac ethyl adn aspirin DL-lysine showed a spike or spike and wave complex in EEG without showing remarkable behavioral changes when they were injected intraventricularly, although a relatively high dose was needed. Enoxacin, on the other hand, elicited potent epilept ogenic activity characterized by uninterrupted high voltage spike and wave complex at doses of 50 and 100 mu g. At the same time,rats showed hyperactivity, jumping and violent convulsion. Combined treatment wit h enoxacin (p.o.) and ferubinac ethyl (i.v.) caused potent epileptogen ic activity characterized by uninterrupted burst of high voltage spike and wave complex. Behaviorally, animals showed forelimb clonus, head nodding and generalized convulsion. High voltage spike and wave comple x was also observed after combined treatment with enoxacin (i. vent.) and ferubinac ethyl (i.v. or i. vent) in association with hyperactivit y and jumping and violent convulsion. Nicardipine remarkably inhibited epileptic seizures induced by combined treatment with enoxacin (p.o) and ferubinac ethyl (i.v.). It is concluded that simultaneous treatmen t with enoxacin and ferubinac ethyl produced epileptogenic activity wh en injected intraventricularly, and nicardipine inhibited convulsions induced by combined use of enoxacin (p.o.) and ferubinac ethyl (i.v.).