SYNTHESIS AND BIOLOGICAL EVALUATION OF NEW FRAGMENTS FROM KIRROMYCIN ANTIBIOTIC

New N-acyl derivatives of 1-N-desmethyl goldinamine were obtained from degradation of kirromycin. Periodate-oxidation of these derivatives p rovided new aldehydic fragments that were further elaborated. Both N-p henyl ureido and N-phthalimido derivatives of 1-N-desmethyl goldinamin e are able to inhibit bacterial protein synthesis in cell-free assay a nd are active against whole microorganisms, although with lower potenc y than kirromycin. The derivatives from the aldehydic fragments are to tally inactive.