NOVEL C-2 SUBSTITUTED CARBAPENEM DERIVATIVES .1. SYNTHESIS AND BIOLOGICAL-ACTIVITY OF NONAROMATIC HETEROCYCLIC-DERIVATIVES

Authors
BURTON G CLEAR NJC EGLINGTON AJ GUEST AW HUNT E NAYLOR A PEARSON MJ TAKLE AK
Citation
G. Burton et al., NOVEL C-2 SUBSTITUTED CARBAPENEM DERIVATIVES .1. SYNTHESIS AND BIOLOGICAL-ACTIVITY OF NONAROMATIC HETEROCYCLIC-DERIVATIVES, Journal of antibiotics, 49(12), 1996, pp. 1258-1265
Citations number
16
Categorie Soggetti
Pharmacology & Pharmacy",Immunology,"Biothechnology & Applied Migrobiology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
49
Issue
12
Year of publication
1996
Pages
1258 - 1265
Database
ISI
SICI code
0021-8820(1996)49:12<1258:NCSCD.>2.0.ZU;2-Z
Abstract
A new series of carbapenems, having a saturated or partially unsaturat ed heterocycle at C-2, has been synthesised. The in vitro antibacteria l activity of these compounds and their stability to human dehydropept idase-1 (DHP-1) are described. The stereochemistry of the C-2 side-cha in and the presence of a double bond in the heterocycle were shown to have significant effects on the stabilities of the compounds to DHP-1.