I. Effendy et al., EFFECTS OF CALCIPOTRIOL ON STRATUM-CORNEUM BARRIER FUNCTION, HYDRATION AND CELL RENEWAL IN HUMANS, British journal of dermatology, 135(4), 1996, pp. 545-549
Calcipotriol, a vitamin D analogue utilized for psoriasis, has irritat
ion as its most frequent reported adverse event, However, studies on i
ts irritant properties in humans have produced conflicting data, This
study evaluates the effect of calcipotriol on stratum corneum barrier
function, hydration and cell turnover in healthy volunteers, compared
with sodium lauryl sulphate (SLS) as a model irritant, Calcipotriol 0.
005% ointment and 1% aqueous SLS solution were applied for 60 min once
daily for 2 weeks (5 consecutive days weekly) on untreated and on dan
syl-chloride-labelled skin. Irritant responses were documented by visu
al scoring and by measurement of the transepidermal water loss (TEWL)
and stratum corneum hydration (electrical capacitance), until day 18.
Stratum corneum turnover time (SCTT) was the time in days between stai
ning (day 0) and the disappearance of dansyl fluorescence. SLS caused
more erythema, scaling, and a significant TEWL increase for 18 days, I
n contrast, calcipotriol induced erythema, and slightly but significan
tly increased TEWL on day 11 only, as compared with the vehicle contro
l (P < 0.05), SLS, but not calcipotriol, caused skin dryness from day
4 to day 18, The shortest SCTT was obtained at SLS-exposed sites (11.2
+/-0.7 days: mean +/- SD), Calcipotriol significantly shortened SCTT (
16.3 +/- 1.1 days) when compared with its vehicle. Compared with the s
kin irritation induced by SLS, under these test conditions, calcipotri
ol is a far weaker irritant on normal human skin, In addition, calcipo
triol accelerates stratum corneum turnover to a significantly greater
extent than its vehicle.