A NONSENSE MUTATION (ARG-196-TERM) IN EXON-6 OF THE HUMAN TP53 GENE IDENTIFIED IN SMALL-CELL LUNG-CARCINOMA

In a search for mutations of the TP53 tumour suppressor gene in lung c ancer samples from gold miners from the Witwatersrand, South Africa, u sing heteroduplex and single strand conformation polymorphism (SSCP) a nalysis, a nonsense mutation was found in exon 6, consisting of a C to T transition and resulting in chain termination of the TP53 gene. The mutation occurred in a small cell lung cancer sample and is the first reported codon 196 TP53 mutation in both radon-associated and small c ell lung cancer (SCLC) material. (C) 1996 Academic Press Limited