SUBACUTE EXPOSURE TO CADMIUM CHLORIDE INDUCES HSP-72 IN RAT-LIVER

Authors
CURTIS SL NONAVINAKERE VK POTMIS RA RASEKH HR REAMS R EARLY JL
Citation
Sl. Curtis et al., SUBACUTE EXPOSURE TO CADMIUM CHLORIDE INDUCES HSP-72 IN RAT-LIVER, Research communications in molecular pathology and pharmacology, 94(2), 1996, pp. 221-224
Citations number
7
Categorie Soggetti
Pharmacology & Pharmacy",Pathology,Biology
Journal title
Research communications in molecular pathology and pharmacology → ACNP
ISSN journal
10780297
Volume
94
Issue
2
Year of publication
1996
Pages
221 - 224
Database
ISI
SICI code
1078-0297(1996)94:2<221:SETCCI>2.0.ZU;2-W
Abstract
Two groups of rats (n=5) weighing 175-185g were implanted (sc) with os motic minipumps to deliver (0.5 mu l/hr) deionized water or cadmium ch loride (CdCl2; 0.2 M) for 14 days. On completion of subacute treatment , liver and kidneys were collected from control and CdCl2 treated grou ps for analysis. We report that, subacute exposure to CdCl2 results in significant Cd accumulation in liver and kidneys, and heat-shock-prot ein 72 (HSP-72) induction in the liver. Results affirm a role for live r HSP-72 in Cd-toxicity.