SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME ETHYL 2-ARYLAMINO-5-BROMO IODOTHIAZOLE-4-CARBOXYLATES/

Authors
BADDI MM MAHAJANSHETTI CS
Citation
Mm. Baddi et Cs. Mahajanshetti, SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME ETHYL 2-ARYLAMINO-5-BROMO IODOTHIAZOLE-4-CARBOXYLATES/, Indian Journal of Heterocyclic Chemistry, 6(1), 1996, pp. 67-70
Citations number
2
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Indian Journal of Heterocyclic Chemistry → ACNP
ISSN journal
09711627
Volume
6
Issue
1
Year of publication
1996
Pages
67 - 70
Database
ISI
SICI code
0971-1627(1996)6:1<67:SAAAOS>2.0.ZU;2-S
Abstract
Bromination of ethyl 2-arylaminothiazole-4-carboxylates (I) in glacial acetic acid gives HBr salts of 5-bromo derivatives (II) while iodinat ion of I by iodine monochloride in aq HCl gives HI salts of 5-iodothia zole derivatives (IV). Free bases III and V are obtained by basificati on of II and IV respectively. Five selected compounds from II, III, IV and V have been screened for their antifungal and antibacterial activ ity.