Objective: To validate the TRISS method as an audit system on a group
of patients with severe trauma admitted to an Italian general intensiv
e care unit (ICU). Design: Prospective, cohort study of consecutive ad
missions to the ICU. Setting: A 6-bed general ICU in a 500-bed general
hospital. Patients: 190 patients with severe trauma admitted from Jan
uary 1992 to December 1993 were considered eligible. Patients lacking
the data necessary to calculate the TRISS probability of survival, or
for whom the ultimate outcome was unknown, were excluded. 162 patients
were included in the study. Interventions: None. Outcome measure: Vit
al Status at discharge from the last hospital that admitted the patien
t for the trauma being considered. Results: The Hosmer-Lemeshow goodne
ss-of-fit tests were: (H) over cap = 16.9, df = 10, p = 0.076; (C) ove
r cap = 5.8, df = 10, p = 0.831. (H) over cap 3.5, df = 3, p = 0.31. T
he area under the receiver operating characteristic curve was 0.963 (S
E +/- 0.019). Classification measures at a decision criterion of 0.5 w
ere. sensitivity 0.857, specificity 0.964, positive predictive value 0
.782, negative predictive value 0.978, total correct classification 0.
950, and the Youden index 0.831. The positive likelihood ratio (LHR) w
as 24.17, whereas the negative LHR was 0.14. Conclusions: The results
of the validation of the TRISS method showed adequate calibration and
high discriminatory power in Italian ICU trauma patients also, allowin
g confidence in the use of this method as an audit tool in our ICU. So
me caution is advisable in extending these results to patients with op
erable intracranial injuries, due to the relatively low number of such
cases included in the study.