Charts of 320 patients with corneal ulcers seen on the Cornea Service
of Wills Eye Hospital from July 1, 1992, to June 30, 1995, were review
ed retrospectively. Of these cases, 96 (30%) were associated with cont
act lens use. Ulcers in contact lens users accounted for 36% of cases
in the last 6 months of 1992 and all of 1993, 20% of cases in 1993, an
d 29% in the first 6 months of 1995. The contact lenses most commonly
associated with ulcers were disposable extended-wear lenses. They were
used in 33% of contact lens-associated ulcers in 1992 27% in 1993, 39
% in 1994, and 44% in 1995. Pseudomonas was the predominant organism p
rior to 1993 (1-4). From 1993 to 1995, however, the number of Pseudomo
nas ulcers steadily decreased. Two or three Acanthamoeba infections co
ntinue to be treated each year. There has been a significant decrease
in the number of contact lens-related ulcers treated at our institutio
n compared with previous years (p < 0.01) (3,4).