Methodologies to obtain DNA sequence information efficiently and accur
ately will provide the basis for a broad spectrum of economical produc
ts and applications to a variety of industrial sectors, in addition to
healthcare. Such technologies will build upon the evolving molecular
biology and instrumentation base that is serving a specific research m
arket. This will require the efficient integration of technical advanc
es in microchemistry, micromachining, separation technologies, detecti
on systems, microelectronics and information technology, and will invo
lve the expertise of engineers, physicists, chemists, mathematicians,
computer scientists and molecular biologists. The biotechnology, micro
electronics, software, instrumentation, pharmaceutical and fine chemic
al industries will be vital to this development.