INTERMOLECULAR CARBONYL-ENE APPROACH TO THE BICYCLIC ANALOGS OF ENEDIYNE ANTIBIOTICS, NEOCARZINOSTATIN, C-1027, AND KEDARCIDIN - HIGHLY DIASTEREOSELECTIVE CARBONYL-ENE REACTION WITH AN ALKYNE-COBALT COMPLEX

Authors
MIKAMI K FENG F MATSUEDA H YOSHIDA A GRIERSONT DS
Citation
K. Mikami et al., INTERMOLECULAR CARBONYL-ENE APPROACH TO THE BICYCLIC ANALOGS OF ENEDIYNE ANTIBIOTICS, NEOCARZINOSTATIN, C-1027, AND KEDARCIDIN - HIGHLY DIASTEREOSELECTIVE CARBONYL-ENE REACTION WITH AN ALKYNE-COBALT COMPLEX, Synlett, (9), 1996, pp. 833
Citations number
87
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synlett → ACNP
ISSN journal
09365214
Issue
9
Year of publication
1996
Database
ISI
SICI code
0936-5214(1996):9<833:ICATTB>2.0.ZU;2-T
Abstract
The alkoxy(methyl)aluminum chloride promoted intermolecular carbonyl-e ne reaction of a conjugated ynal enophile bearing terminal ester funct ion with an alkyne-cobalt complexed ene component is found to be highl y erythro-diastereoselective, producing a multifunctionalized product which can be efficiently elaborated to the enediyne cores of neocanino statin, C-1027, and kedarcidin.