DIRECT SYNTHESIS OF METAL-COMPLEXED AROMATIC AMINO-ACID DERIVATIVES BY PALLADIUM-CATALYZED COUPLING PROCESSES

Authors
JACKSON RFW TURNER D BLOCK MH
Citation
Rfw. Jackson et al., DIRECT SYNTHESIS OF METAL-COMPLEXED AROMATIC AMINO-ACID DERIVATIVES BY PALLADIUM-CATALYZED COUPLING PROCESSES, Synlett, (9), 1996, pp. 862
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synlett → ACNP
ISSN journal
09365214
Issue
9
Year of publication
1996
Database
ISI
SICI code
0936-5214(1996):9<862:DSOMAA>2.0.ZU;2-7
Abstract
Palladium(O) catalysed coupling of the serine-derived organozinc reage nt 3 with 1-iodoferrocene and 1,1'-diiodofenocene gave the correspondi ng protected ferrocenylalanine and 1,1'-ferrocenylbis(alanine) derivat ives 6 and 8, respectively. Analogous coupling of (haloarene)tricarbon ylchromium complexes with zinc reagent 3, and subsequent decomplexatio n, gave phenylalanine derivatives 11, including the 2-fluorophenylalan ine derivative 11b.