ITA
ENG

SYNTHETIC APPROACHES TO RAPAMYCIN .3. SYNTHESIS OF A C1-C21 FRAGMENT

Authors

HARRIS L JAROWICKI K KOCIENSKI P

Citation

L. Harris et al., SYNTHETIC APPROACHES TO RAPAMYCIN .3. SYNTHESIS OF A C1-C21 FRAGMENT, Synlett, (9), 1996, pp. 903

Citations number

Categorie Soggetti

Chemistry Inorganic & Nuclear

Journal title

Synlett → ACNP

ISSN journal

09365214

Issue

Year of publication

1996

Database

ISI

SICI code

0936-5214(1996):9<903:SATR.S>2.0.ZU;2-#

Abstract

Key steps in two alternative approaches to the C10-C21 fragments 4 and 17 of the immunosuppressant rapamycin employ catalytic asymmetric all ylation and catalytic asymmetric hydrogenation to introduce the first stereogenic centre at C14. Appendage of C1-C9 via trapping of an a-oxo ketene intermediate generates the C1-C21 fragment 5.