Although chronic arterial hypertension is the leading cause of intracr
anial hemorrhage, an abrupt rise in systemic arterial pressure in norm
otensive people may sometimes induce a hemorrhagic stroke, Dental trea
tment is rarely associated with such an event. We report here on two m
iddle-aged women, apparently healthy, who suffered from a fatal intrac
erebral hemorrhage following a dental treatment, On admission, high le
vels of arterial hypertension were found. It seems that trigeminal man
ipulation during dental treatment as well as increased serum levels of
induced epinephrine mainly by stress and pain, and the small amounts
absorbed from the site of local anesthesia might produce abrupt elevat
ion of blood pressure, subsequent increase in cerebral blood flow and
severe, even fatal intracerebral hemorrhage. The addition of catechola
mines to local anesthetics should be considered. We recommend the use
of benzodiazepin as a premedication drug to reduce stress during denta
l treatment.