LIPID-PEROXIDATION AS A POTENTIAL ENDOGENOUS SOURCE FOR THE FORMATIONOF EXOCYCLIC DNA-ADDUCTS

A number of promutagenic exocyclic DNA adducts have recently been dete cted in both humans and rodents without carcinogen treatment. These ob servations raised questions about their origins and potential signific ance in carcinogenesis, In this commentary, we present our views perta ining to the in vivo sources of these cyclic adducts, specifically the cyclic propane and etheno adducts, The basis for our discussion comes mainly from the information generated through a span of more than a d ecade from several laboratories, including ours, This commentary summa rizes the data from the chemical and biochemical studies that provide support for the hypothesis that lipid peroxidation is involved in the endogenous formation of these exocyclic adducts.